Endocrine Abstracts

Low plasma sex hormone-binding globulin (SHBG) levels are present in patients suffering chronic metabolic diseases, including non-alcoholic fatty liver disease (NAFLD). However, whether altered SHBG production plays a role in development and progression of this disease is unclear. To investigate SHBG involvement in NAFLD, we studied the effects of overexpressing SHBG in two mouse models, a genetically-induced model, by developing a double transgenic mouse by crossing the human...